NIZATIDINE
Axid® AR [OTC]; Axid®


DOSING IN ADULTS

GERD 150 mg twice daily
Duodenal ulcer-  Treatment of active ulcer: 300 mg at bedtime or 150 mg twice daily
  Maintenance of healed ulcer: 150 mg/day at bedtime
Gastric ulcer -150 mg twice daily or 300 mg at bedtime
Meal-induced heartburn, acid indigestion, and sour stomach (OTC labeling): Oral: 75 mg tablet [OTC] twice daily, 30-60 minutes prior to consuming food or beverages


DOSING IN  RENAL IMPAIRMENT
150 mg every other day


DOSAGE FORMS 

Capsule (Axid®): 150 mg, 300 mg
Solution, oral (Axid®): 15 mg/mL (120 mL, 480 mL) [bubble gum flavor]
Tablet (Axid® AR): 75 mg


SIGNIFICANT ADVERSE REACTIONS

Headache
Anxiety
Pruritus
Rash
Abdominal pain
Gynecomastia


CONTRAINDICATIONS — Hypersensitivity to nizatidine or any component of the formulation; hypersensitivity to other H2 antagonists (cross-sensitivity has been observed)


DRUG INTERACTIONS 

Antifungal agents (imidazole): Nizatidine may decrease the absorption of itraconazole or ketoconazole.
Atazanavir: Histamine H2 antagonists may decrease the absorption of atazanavir.


PREGNANCY RISK FACTOR — B


LACTATION — Enters breast milk/may be compatible.