LUBIPROSTONE
Amitiza


DOSING IN  ADULTS
 
Idiopathic constipation-24 mcg twice daily ( to be taken with food)
Irritable bowel Syndrome ( in women > 18 years )-8 mcg thrice a day


DOSAGE FORMS 

24 mcg, 8 mcg

SIGNIFICANT ADVERSE REACTIONS

Headache
Nausea
Diarrhea
Edema


CONTRAINDICATIONS — Hypersensitivity to lubiprostone or any component of the formulation; known mechanical bowel obstruction


PREGNANCY RISK FACTOR — C

Women of childbearing potential should have a negative pregnancy test prior to starting therapy and should be capable of complying with effective contraception.


LACTATION — Excretion in breast milk unknown/not recommended.