HYOSCYAMINE
Anaspaz, Levbid, Levsin/SL, Levsinex, Levsin, NuLev


DOSING IN  ADULTS
  Oral or S.L.: 0.125-0.25 mg every 4 hours or as needed (before meals or food); maximum: 1.5 mg/24 hours
  Oral, timed release: 0.375-0.75 mg every 12 hours; maximum: 1.5 mg/24 hours


DOSAGE FORMS 

Capsule, timed release, as sulfate (Levsinex): 0.375 mg
Elixir, as sulfate: 0.125 mg/5 mL (480 mL)
  Levsin: 0.125 mg/5 mL (480 mL) [contains alcohol 20%; orange flavor]
Tablet, as sulfate (Anaspaz, Levsin): 0.125 mg
Tablet, extended release, as sulfate (Levbid) 0.375 mg
Tablet, orally disintegrating, as sulfate (NuLev): 0.125 mg [contains phenylalanine 1.7 mg/tablet, mint flavor]
Tablet, sublingual, as sulfate: 0.125 mg


SIGNIFICANT ADVERSE REACTIONS 

Dry mouth
Palpitation
Dizziness
 Lactation suppression
Bloating
Constipation
Urinary retention
Blurred vision
Decreased Sweating


CONTRAINDICATIONS — Hypersensitivity to belladonna alkaloids or any component of the formulation; glaucoma; obstructive uropathy; myasthenia gravis; obstructive GI tract disease, paralytic ileus, unstable cardiovascular status in acute hemorrhage, myocardial ischemia


DRUG INTERACTIONS

Antacids: Antacids may decrease absorption of hyoscyamine; administer hyoscyamine before meals and give antacids after meals.
Antihistamines: Additive adverse effects may occur with some antihistamines due to cholinergic blockade.
Antimuscarinics: Additive adverse effects may occur due to cholinergic blockade.
Haloperidol: Additive adverse effects may occur due to cholinergic blockade.
Phenothiazines: Additive adverse effects may occur due to cholinergic blockade.
Tricyclic antidepressants: Additive adverse effects may occur due to cholinergic blockade.


PREGNANCY RISK FACTOR — C


LACTATION — Enters breast milk/not recommended